eQuilibrator--the biochemical thermodynamics calculator
نویسندگان
چکیده
منابع مشابه
eQuilibrator—the biochemical thermodynamics calculator
The laws of thermodynamics constrain the action of biochemical systems. However, thermodynamic data on biochemical compounds can be difficult to find and is cumbersome to perform calculations with manually. Even simple thermodynamic questions like 'how much Gibbs energy is released by ATP hydrolysis at pH 5?' are complicated excessively by the search for accurate data. To address this problem, ...
متن کاملThermodynamics of Computational Copying in Biochemical Systems
Living cells use readout molecules to record the state of receptor proteins, similar to measurements or copies in typical computational devices. But is this analogy rigorous? Can cells be optimally efficient, and if not, why? We show that, as in computation, a canonical biochemical readout network generates correlations; extracting no work from these correlations sets a lower bound on dissipati...
متن کاملThe thermodynamics of computational copying in biochemical systems
Living cells use readout molecules to record the state of cell-surface receptors that detect ligands in their environment. On the surface, these readouts appear similar to measurements made by computational devices, as extensively studied in the literature following Maxwell’s demon. But at what level do measurements made by biochemical devices map onto computational measurements made, for examp...
متن کاملEffects of pH in Biochemical Thermodynamics and Enzyme Kinetics
In biochemical thermodynamics, the apparent equilibrium constants of enzyme-catalyzed reactions have been represented by K’=Kref10 f(pH), where Kref is a reference chemical reaction, n is the number of hydrogen ions in the reference reaction, and f(pH) is a function of pH that brings in the pKs of the substrates. This equation suggests that hydrogen ions are involved in two different ways in bi...
متن کاملThe Calculator Demo
Due to its open character, TEX can act as an authoring tool. This article demonstrates that by integrating TEX, METAPOST, JavaScript and PDF, one can build pretty advanced documents. More and more documents will get the characteristics of programs, and TEX will be our main tool for producing them. The example described here can be produced with PDFTEX as well as traditional TEX. Introduction Wh...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2011
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkr874